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"Cell-penetrating CNTs for delivery of therapeutics" posted by ~Ray
Posted on 2008-01-01 23:14:11

Technologically important nanomaterials come in all shapes and sizes. They can range from small molecules to complex composites and mixtures. Depending upon the spatial dimensions of the system and properties under investigation computer modeling of such materials can range from equilibrium and non-equilibrium quantum mechanics to force-field-based molecular mechanics and kinetic Monte Carlo mesoscale simulation of evolving morphology and finite-element computation of physical properties. This brief review illustrates some of the above modeling techniques through a be of recent applications with carbon nanotubes: nano electromechanical sensors (NEMS) chemical sensors coat–nanotube contacts and polymer–nanotube composites. In reduced dimensions materials show characteristics quite different from their bulk behavior. Interestingly most viruses bacteria pathogens particles in gas phase and other chemical–biological agents which create the basis of this investigation also have comparable dimensions. Our present and ongoing investigation is aimed towards the detection of chemical and biological agents using nanostructured materials. We undergo studied nanotubes nanoparticles nanowires and nanoporous materials for biocompatibility and subsequent detection. In addition based on our field emission studies on carbon nanotubes we have suggested device designs to detect environmental emission. Detection strategies and preliminary data from electrochemical sensors atomic force microscopy and surface plasmon resonance are presented for the detection of chemical–biological agents immobilized on layers of nanoparticles. As a critical step in the development of sensors/detectors strategies for ascend functionalization and immobilization for carbon nanostructures nanoparticles and nanoporous materials are also presented. Such devices show unique characteristics morphological flexibility and biocompatibility. The eventual objective of our investigation is to develop a nanotechnology based sensor platform that will enable the direct electrical optical or electro-optical detection of biological and chemical agents in a label-free highly multiplexed change over a broad dynamic range. Vertically aligned carbon nanotubes were grown on the Cr-coated glass substrate with different thickness of Ni catalyst forge at low temperatures (<600 °C) using plasma-enhanced hot filament chemical vapor deposition (PEHFCVD). The diameter of carbon nanotubes.


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"Cell-penetrating CNTs for delivery of therapeutics" posted by ~Ray
Posted on 2007-12-09 14:05:27

Technologically important nanomaterials come in all shapes and sizes. They can range from small molecules to complex composites and mixtures. Depending upon the spatial dimensions of the system and properties under investigation computer modeling of such materials can range from equilibrium and non-equilibrium quantum mechanics to force-field-based molecular mechanics and kinetic Monte Carlo mesoscale simulation of evolving morphology and finite-element computation of physical properties. This brief review illustrates some of the above modeling techniques through a be of recent applications with carbon nanotubes: nano electromechanical sensors (NEMS) chemical sensors metal–nanotube contacts and polymer–nanotube composites. In reduced dimensions materials display characteristics quite different from their bulge behavior. Interestingly most viruses bacteria pathogens particles in gas phase and other chemical–biological agents which create the basis of this investigation also have comparable dimensions. Our present and ongoing investigation is aimed towards the detection of chemical and biological agents using nanostructured materials. We have studied nanotubes nanoparticles nanowires and nanoporous materials for biocompatibility and subsequent detection. In addition based on our field emission studies on carbon nanotubes we have suggested device designs to detect environmental emission. Detection strategies and preliminary data from electrochemical sensors atomic compel microscopy and surface plasmon resonance are presented for the detection of chemical–biological agents immobilized on layers of nanoparticles. As a critical step in the development of sensors/detectors strategies for surface functionalization and immobilization for carbon nanostructures nanoparticles and nanoporous materials are also presented. Such devices show unique characteristics morphological flexibility and biocompatibility. The eventual objective of our investigation is to develop a nanotechnology based sensor platform that will enable the direct electrical optical or electro-optical detection of biological and chemical agents in a label-free highly multiplexed change over a broad dynamic range. Vertically aligned carbon nanotubes were grown on the Cr-coated glass substrate with different thickness of Ni catalyst forge at low temperatures (<600 °C) using plasma-enhanced hot filament chemical vapor deposition (PEHFCVD). The diameter of carbon nanotubes grown for 14 min increased from 32 to 113 nm as the thickness of Ni layer increased form 10 to 100 nm. However the diameter of carbon nanotubes grown for 34 min was almost same irrespective of Ni layer thickness. The emission characteristics of carbon nanotubes (CNTs) were dependent on the diameter of carbon nanotubes and substrate. Turn on electric handle. E The use of carbon-based nanostructures such as carbon nanotubes in biomedicine is increasingly attracting attention. One key advantage of carbon nanotubes is their ability to shift through plasma membranes allowing their use for the delivery of therapeutically active molecules in a manner that resembles cell-penetrating peptides. Moreover exploitation of their unique electrical optical thermal and spectroscopic properties in a biological context is hoped to yield great advances in the detection monitoring and therapy of disease. Here we furnish a speculative overview of the general principles behind the mechanism of carbon nanotube penetration of the plasma membrane and a snapshot of the different therapeutic modalities based on these fascinating nanostructures that are currently being investigated. Determination of the claim mechanism leading to cellular internalization of CNTs is considered of great importance in their continued development as components of biomedical devices and therapeutics intended for implantation or administration to patients. The most important parameter in all such studies is the type of carbon nanotubes used which is determined by: (i) the preparation and manufacturing affect followed; (ii) the structural characteristics of the CNTs; and (iii) the surface characteristics of the CNTs and the characteristics of the functional groups at the ascend of CNTs. Interactions with cells undergo to be performed using biocompatible CNTs achieved by either covalent or noncovalent ascend functionalization to produce water-soluble CNTs. A variety of different functionalization strategies for CNTs have been reported by various groups therefore enjoin comparisons are often hampered by the inability to correlate experimental conditions. The covalent functionalization of CNTs can generally be achieved by two main approaches: (i) esterification or amidation of oxidized tubes; and (ii) sidewall covalent attachment of functional groups. Regarding the first come the oxidation process is conducted under strong acid conditions which induce the opening of CNT end-caps generating carboxylic groups suitable for further derivatization. In addition carboxylic functions are created where defects in the nanotube sidewalls are show. On the other hand the direct sidewall functionalization of CNTs with organic groups is possible using reactive species such as nitrenes carbenes and radicals. To this end alkyl azides dipyridyl imidazolium salts and perfluoroalkyl radicals undergo been employed as efficient reagents. The high wet dispersibility of the resulting modified CNTs can be explained by the debundling/unroping that occurs via mutual electrostatic repulsion of the CNT surfaces and their ability to accommodate water molecules. Other strategies to achieve sidewall functionalization of CNTs use a variety of chemical routes such as the 1,3-dipolar cycloaddition of azomethine ylides. The easiest way to alter such derivatives is the decarboxylation of immonium salts obtained by the reaction of an a-amino acid with an aldehyde. In particular a glycine modified at the N-terminus with a mono N-Boc-protected diaminotriethylene glycol has been proposed because of its high solubilizing capacity after removal of the Boc group. The free amino function dramatically increases the solvent compatibility of both SWNTs and MWNTs which are come up dispersed in aqueous solvents and available for further derivatization. In several functionalized derivates of CNTs that can be adequately and individually dispersed in wet are shown. Only since the issue of CNT compatibility with the aqueous biological environment was adequately beat has it become possible to explore their interaction with living cells. We have experimentally observed that CNTs are able to interact with plasma membranes and cross into the cytoplasm without the apparent need of engulfment into a cellular compartment to aid intracellular transport. In these initial studies functionalized CNTs are able to aid transport of plasmid DNA (pDNA) intracellularly. Interestingly copy nanotube structures have also been proposed to interact with lipid bilayers via a diffusion process directly through the biomembrane as illustrated in Spontaneous transmembrane penetration via the flipping of membrane lipid molecules is contrary to endocytosis an energy-independent process not dependent on receptor cover or lipid raft interactions and is therefore potentially relevant to all cell types. Lopez et al undergo described the spontaneous diffusion of nanotubes functionalized with hydrophilic termini.


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"US Has Super Penetrating Bomb" posted by ~Ray
Posted on 2007-11-09 18:32:49

Sunday. September 16. 2007 - FreeMarketNews com The U. S has a 14-ton super bomb more destructive than the clean bomb just tested by Russia a U. S command said Wednesday. The statement was made by retired Lt. command McInerney chairman of the Iran Policy Committee and former Assistant Vice Chief of Staff of the Air compel. McInerney said the U. S has "a new massive ordnance penetrator that's 30,000 pounds that really penetrates... Ahmadinejad has nothing in Iran that we can't penetrate." He also said the new Russian bomb was not a "penetrator." -Rense


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Posted on 2007-11-05 18:41:25



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"Greg Osby - 'Penetrating Stare'" posted by ~Ray
Posted on 2007-11-03 14:31:19

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"Iraq War: Armor-Penetrating Grenades from Russia Used by Al-Qadea" posted by ~Ray
Posted on 2007-10-10 17:13:04

Al-Qaeda forces known as the “,” undergo begun employing a new weapon against U. S troops. Armor-penetrating grenades are small hand-held explosives with a shaped rush capable of penetrating a vehicle’s roof. The new grenade is of Russian origin. The new armor-penetrating grenade is thrown then: “utilizes a parachute to lie the grenade and allow it to alter a controlled descent onto the top of the aim (i e armored vehicle). Once it makes contact the grenade uses a shaped rush to penetrate the vehicle’s roof. CBS News is reporting that the grenade also uses a slow-burning explosive charge to enhance the lethal effect when the shaped charge penetrates into the interior of the vehicle. So the grenade is more accurately described as a hand-thrown shaped-charge grenade.” The new armor-penetrating grenades have been used against the U. S. Army’s in the of Baghdad. In addition to the lethality of the weapon it has the favor of being capable of being carried and with little risk of detection. One Response to “Iraq War: Armor-Penetrating Grenades from Russia Used by Al-Qadea” mullah cimoc say usa war news blockade so end all ameriki just the be ignorance. but the punish come change surface now for love the blackball and the torture wife the lesbian dislike man never cook the food ameriki him daughter she act the LBT (low back tattoo) now slut and sex with every man even the gang member. arrive go back to maya and aztec whitie to be kill muslim not to do this ameriki whitie him exterminate hisself-abortion kill the do by the son him just the gay homosexual not the grand children for the happy family. only him braveheart if coming to saving the ameriki now first job destroy all usa re-create news people to educating him ameirki. for true and end the info: XHTML: You can use these tags: <a href="" call=""> <abbr title=""> <acronym title=""> <b> <blockquote have in mind=""> <cite> <label> <del datetime=""> <em> <i> <q cite=""> <touch> <strong>


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"Iraq War: Armor-Penetrating Grenades from Russia Used by Al-Qadea" posted by ~Ray
Posted on 2007-10-06 09:10:31

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"Solar Focus sees solar penetrating to consumer electronics" posted by ~Ray
Posted on 2007-10-03 18:48:14

Sorry the summon you are trying to open is available only for our paid subscribers. With comprehend adorn applications becoming more popular recently. Taiwan-based touch panel-related companies such as Empia Technology. Mildex Optical. Swenc Technology and J comprehend are planning to enumerate on the emerging over-the-counter (OTC) and main boards of the Taiwan Stock transfer (TSE) in the future according to the companies and sources. HTC Touch handsets made by High Tech Computer (HTC) had shipments of 800,000 units in the first three months after open according to sources at handset makers. Nvidia is planning to open the AMD platform-based MCP72 IGP (integrated graphics processor) chipset at the end of November or the beginning of December this year with crowd production to start ahead in November according to sources at motherboard makers. Telecom - Newswatch | Oct 3. 16:32 High Tech Computer (HTC) projects it will ship 15 million smartphones in 2008 up 30% from the shipment volume projected for 2007 the Chinese-language... Acer said it has purchased up to 80.68% of Gateway's outstanding common shares as of October 1 and that it is extending the deadline for the company's... The mobile telecommunicate show divide was shaken by a 36% on quarter and 41% on year displace in Motorola's mobile telecommunicate main display purchases drink from 50 million... Bits + chips | Oct 3. 11:11 Taiwan-based Global Unichip has received orders for handset-use mobile TV chips from an IDM working for Samsung Electronics according to merchandise sourc... Due to the explosive growth in consumer demand for LCD digital TVs (DTVs) the merchandise for semiconductors used in such TV sets is expected to change... Bits + chips - Newswatch | Oct 3. 10:28 Taiwan-based Phison Electronics received go orders for 300,000 memory card controller ICs from a Chinese client on the first day of China's week-long... Apple reportedly is considering adopting Intel's Moorestown MID (mobile Internet device) platform processor in a new iPhone according to OEM sources. Bits + chips | Oct 3. 01:00 Sinoar has held the opening ceremony at its new thin-film solar production lay at Hsinchu. Taiwan. The company ordain soon register volume production with... Monitor and 32-inch TV panel prices in October are expected to continue September's upward turn because of persisting demand according to industry sources. The sources pointed out that in September observe and notebook adorn prices increased US$1-5 while 32-inch TV panel prices went up US$5. Notebook makers in Taiwan do not evaluate the fire at the Osaka lay of a Matsushita Electric subsidiary to force the notebook market according to industry sources. AMD is preparing to open its new Radeon HD 2950PRO (RV670) chip on November 19 according to sources at graphics separate makers. The affiliate recently notified graphics separate makers that design verification evaluate (DVT) samples will be sent out at the beginning of this month and AMD ordain start producing a batch of 1.5 million chips in the first week of November. Bits + chips | Oct 2. 15:31 After launching a solar-grade silicon feedstock material derived from metallurgical silicon. PV 1101 last year. Dow Corning anticipates that capacity... Bits + chips | Oct 2. 11:55 Sony and Qimonda announced that they have signed an agreement to open a fit go (JV). Qreatic Design in lacquer for the design of high-performance,... Although the portable entertainment consumer electronics market will top 500 million units in 2008 growth momentum will wane through 2009 as the mainstream... Bits + chips | Oct 2. 11:36 While seeing fierce competition in printed go come in (PCB) production related to networking and communication devices. Chin-Poon Industrial and Unitech... Since AMOLED panels undergo advantages such as being lightweight thin and energy efficient. Chi Mei EL Corporation (CMEL) is eyeing the mobile TV market... LCD TV vendors are pushing products in China at the beginning of October during a national week-long holiday by slashing prices according to sources. Displays - Newswatch | Oct 2. 10:02 Taiwan-based alter filter (CF) maker Allied Material Technology Corporation (AMTC) ordain restart its fifth-generation (5G) lay in the middle of November... innovate which has developed products in the plasma TV merchandise for 10 years will not rule out the possibility of developing products for the LCD TV market... As the third-largest semiconductor equipment supplier after Applied Materials and Tokyo Electron Limited (TEL) and a leading player in the immersion lithography handle. ASML has a alter direction for its future. The equipment supplier reiterated that it believes extreme ultraviolet (EUV) will change state the next mainstream lithography technology when the industry advances create by mental act geometries. President of the affiliate's Asia operations since April. Larry Tan of Texas Instruments (TI) believes that a strong relationship with the customer is key for success. Citing a broad customer locate and solid ties with customers. Tan said TI strives to have its sales in Asia beat industry and company sales averages while continuing to change the affiliate's efforts on cutting-edge technology development. Second-tier or third-tier LCD vendors are expected to face a more competitive merchandise during 2008 amid LCD give issues according to sources. Bits + chips | Oct 1. 14:36 The Taiwan International Photovoltaic (PV) Forum & Exhibition 2007 will be held October 11 and 12 in Taipei. Leading solar application makers from... Quanta Computer has no plans to cut expansion at its lay in Changshu. China and ordain act building up capacity of its plant there in phases according... Bits + chips | Oct 1. 11:51 Hynix Semiconductor and Ovonyx undergo announced that they undergo entered into a long-term authorise agreement for memory products under Ovonyx' patents and... Qisda parent company of BenQ has landed orders for a smartphone compliant with the UMA (unlicensed mobile access) standard from a telecom function provider... Bits + chips - Newswatch | Oct 1. 10:45 MJC investigate is said to undergo landed silicon ingot slicing orders from color Energy Technology and Motech Industries with more silicon ingot OEM deals underway,... Displays - Newswatch | Oct 1. 10:32 LCD TV makers now are aggressively seeking sufficient supply for LCD TV panels as supply for 32-inch TV panel is running bunco by 30-40% since panel... CMC Magnetics and Ritek the top two Taiwan-based producers of optical discs as well as Prodisc Technology a second-tier maker are unwilling to invest... Gigastorage a second-tier Taiwan-based maker of optical discs on September 29 announced it has reached a preliminary settlement with Royal Philips...


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"Eva Longoria sex tape?" posted by ~Ray
Posted on 2007-10-02 02:09:54



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"The taming of the cell penetrating domain of the HIV Tat: Myths ..." posted by ~Ray
Posted on 2007-09-30 17:14:36

Protein transduction with cell penetrating peptides over the past several years has been shown to be an effective way of delivering proteins in vitro and now several reports undergo also shown valuable in vivo applications in correcting disease states. An impressive bioinspired phenomenon of crossing biological barriers came from HIV transactivator Tat protein. Specifically the protein transduction domain of HIV Tat has been shown to be a potent pleiotropic peptide in protein delivery. Various approaches such as molecular modeling arginine guanidinium continue group structural strategy multimerization of PTD grade and phage display system have been applied for taming of the PTD. This has resulted in identification of PTD variants which are efficient in cell membrane penetration and cytoplasmic delivery. In arouse of these state of the art technologies the dilemma of low protein transduction efficiency and target specific delivery of PTD fusion proteins remains unsolved. Moreover some misconceptions about PTD of Tat in the literature demand considerations. We undergo assembled critical information on secretory plasma membrane penetration and transcellular properties of Tat and PTD using molecular analysis and available experimental evidences. Keywords: Protein transduction domain (PTD); Nuclear export signal (NES) analysis; Nuclear/nucleolar HIV Tat; Cytoplasmic protein delivery; Lysosomotropic agent; Transcellular-PTD Abbreviations: CPP cell penetrating peptide; CTP cytoplasmic transduction peptide; PTD protein transduction domain; BBB daub–brain barrier; NES nuclear export communicate; NLS nuclear localization communicate; TK thymidine kinase; GUS beta-glucuronidase; LTR desire terminal repeat; HSPGs heparan sulphate proteoglycans.


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"I am responsible for penetrating the marketplace with a mobile ..." posted by ~Ray
Posted on 2007-09-28 15:14:32

My question is two change surface.. I undergo tried to obtain competitors pricing information but unable to do so - what are some suggestions as to pricing model/matrix? should it be based on license volumes recurrring monthly fees? really change state to ideas and suggestionsSecondly since this is a b2b solution and need to get in lie of decision makers - best create of marketing to the specific inudstry? Clint it really does be on your target customer - if you typically target enterprise customers then site licenses is a good way. Customer would definitely have concerns with recurring fee copy. Also beat create of marketing is reaching out to your prospects having identified their business challenges - means are plenty to go away with a smart and driven inside sales team can start identifying a good propects pipeline. Clint,Being totally self-serving here but if you undergo the budget have you considered qualitative market investigate? It would be possible to actually carry your target customer into a research facility and ask them those and many other questions.


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"Indian Social Networks penetrating campuses" posted by ~Ray
Posted on 2007-09-26 15:19:33

has been one such startup which though change state to public is looking to specifically cater to the college going audience. They are trying very hard by launching and most of their mails to users has subjects desire "connect your classmates at So and so college on Minglebox". Their latest act has been where they are asking their users to communicate about their fond memories about teachers. Im sure there ordain be more such initiatives in th future as well. Atleast whats heartening is that they undergo started using their brains for marketing instead of. Another place that is targetting the colleges and especially the chew over abroad students is. This portal which is backed by Northgate Technologies had been in the for being the only social communicate to undergo reached the top 100 sites in India. But their claims are marred by accusations of spamming and to drive merchandise. Bharatstudent com has Campus Awards 2007 as a platform for grading the best schools and colleges across India. According to over 1,00,000 schools and colleges across the country have been considered for the awards. Shortlisted campuses will undergo to nominate themselves with necessary information at the Bharatstudent com/campusawards php. Besides for the above two the latest entrant into campus life has been the Raghav Behl backed youth community that we. Campus18 is actually having representative across colleges to create traction on the place. I not sure if the above sites undergo actually doing anything different than just social networking for college students thereby not adding substantial value than an orkut or a facebook. I accept Communities started by students for their own set of Institutes around a certain hurt inform. This could be communicate sharing notes sharing events admissions or possibly all. I think there is tremendous potential in networking tools linked with need based activities for college goers desire exam dates courses go discussions notes exchanging events projects etc. There are a few small sites that are doing this for a niche audience but nothing there on a large measure. WATblog is a community of bloggers who undergo experience in Internet Advertising and Technology. WATblog will undergo news views and reviews relating to the rapid changes taking place on the web and the interactive advertising space. We ordain also discuss technology be it web or mobile technology. wish you undergo a great time reading :)


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"Fake Goods Penetrating Vietnam All Too Easily" posted by ~Ray
Posted on 2007-09-22 15:31:42

Law enforcement authorities met Friday to address the swell of re-create goods in Vietnam recently a development that has shamed the country’s moves towards stronger intellectual property rights regulations. At a conference on preventing re-create goods in the southern Ba Ria-Vung Tau province Friday delegates warned that the growth of sophisticated copycat items should wake the country up to the be for the protection of intellectual property rights. Fake goods undergo fooled both authorities and consumers and are entering the Vietnamese merchandise freely said Phan Hung Chien vice continue of the Criminal Investigation Bureau under the Ministry of Public Security. Many re-create goods are now more elaborately detailed and designed that ever before according to authorities. Chien expressed serious concern that several popular counterfeit items may undergo seriously adverse health affects on consumers. He cited a rash of recent cases in which food liquor and medicine had been faked in large amounts since early this year. re-create hi-tech goods like motorbikes electronic items. CDs and change surface re-create currency have entered Hanoi and Ho Chi Minh City the country’s two largest markets for re-create goods. An official from the Ministry of Information and Communications said the infringement of intellectual property rights had also became rife in the fields of publishing labeling software movies and art. re-create networks had been expanded abroad and the contend against them was growing stronger all the measure. Chien admitted. Delegates at the conference spoke out against the lack of legal guidelines in prosecuting criminal goods-fakers and counterfeiters. They also pointed their fingers at light fines and easy penalties given to violators saying such measures were not strong deterrents. Insufficient cooperation between enforcement agencies concerned was also to blame some delegates said calling for closer coordination. Since 2002 guard undergo uncovered around 1,000 re-create cases as come up as thousands of intellectual property rights infringements. Source: Thanh Nien


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